Data integration and genomic medicine
نویسندگان
چکیده
منابع مشابه
Methodological Review Data integration and genomic medicine
Genomic medicine aims to revolutionize health care by applying our growing understanding of the molecular basis of disease. Research in this arena is data intensive, which means data sets are large and highly heterogeneous. To create knowledge from data, researchers must integrate these large and diverse data sets. This presents daunting informatic challenges such as representation of data that...
متن کاملGenomic medicine and data sharing
Introduction Effective data sharing does not occur in the UK despite being essential for the delivery of high-quality genomic services to patients across clinical specialities and to optimize advances in genomic medicine. Sources of data Original papers, reviews, guidelines, policy papers and web-resources. Areas of agreement Data sharing for genomic medicine requires appropriate infrastruc...
متن کاملGenomic, Proteomic, and Metabolomic Data Integration Strategies
Robust interpretation of experimental results measuring discreet biological domains remains a significant challenge in the face of complex biochemical regulation processes such as organismal versus tissue versus cellular metabolism, epigenetics, and protein post-translational modification. Integration of analyses carried out across multiple measurement or omic platforms is an emerging approach ...
متن کاملHow Clinical and Genomic Data Integration can Support Pharmacogenomics Efforts Related to Personalized Medicine
Pharmacogenomics is a key factor that will drive the personalized medicine vision. It will help create new combinations of clinical and genomic information necessary for making clinical decision in personalized medicine. Much can be done using available public data sources, yet they lack essential facts that can be only obtained from deep focused curation. A clear distinction will be made betwe...
متن کاملSMART 4.0: towards genomic data integration
SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 protein domains. New developments in SMART are centred on the integration of data from completed me...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2007
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2006.02.007